Which city was the largest and wealthiest city in Europe from the mid-5th century to the early 13th century?

I guess I don't know what 'sacked' means. Ransacked? Books stolen? destroyed or? Then you say it WAS the holder of those holy relics; but do not say if they're still there or if they still exist.

Flower Lady, Constantinople, the jewel of Christianity, was sieged, destroyed, and all inhabitants slaughtered by Islamic invasion. Interestingly, nobody talks about it much.

Flower Lady, was wondering the same thing

greg, the book 1453 by Roger Crowley is a great overview.

Rome would not come to help due to a dispute between Constantine and Rome. The dilute was about how some verse in the service. Thus when he requested aid to defend Constantinople, only supporters from Venice came. Rome did not.

Actually The Ottoman Sultan Mehmed II, known as "Mehmed the Conqueror," captured Constantinople (later renamed Istanbul) in 1453, ending the Byzantine Empire and marking a pivotal moment in history.  Here's a more detailed look: The Conquest: On May 29, 1453, after a 53-day siege, Mehmed II's Ottoman forces breached the city's walls, ultimately conquering Constantinople.  Significance: The fall of Constantinople marked the end of the Byzantine Empire, which had lasted for nearly 1,500 years.  Mehmed II: Mehmed II, a young and ambitious sultan, had already reigned as Sultan in 1444-1446 when Murad II temporarily abdicated to deal with rival Turks in Anatolia.  Strategy: Mehmed's strategy involved blockading the city on all sides with his fleet and siege lines and relentlessly battering the walls with cannon.  Impact: The transformation of Constantinople into the Ottoman capital of Istanbul marked an important new stage in Ottoman history.  Legacy: Mehmed II's conquest of Constantinople is seen as a defining moment in both Ottoman and European history.

The Queen of Cities, Istanbul (was Constantinople)

By the help of the picture, I guessed the right answer!