Which famous painting is known for its enigmatic smile?

Never thought she looked like she was smiling, more a bit fed up.

Ndegwa, It has been said that Leo supposedly used five models for the hands, but it was not a female hand. He may have copied his own hands and some features of the face as well. Maybe he was not being truthful with Mona Lisa's smile is why she looked so dead pan. Who knows?

Seeing it in real life it's small and very unappealing.

this was easy

that smile is the best thing in the picture.