What genetic condition is known as "Guevedoce"?
Correct answer: Female at birth, male by puberty
Iwonder
omg can you imagine what a person with this would go through. my heart is with you.
SilkenTract
Why Dominican republic only?
Player #1380186
That is so interesting. makes me want to research more about it
WhimsicalBruiser9246
Because the genetic pool on an island is limited it's easier for a particular trait to become more prevalent. Immigration bringing trait originally?
ynk
WhimsicalBruiser9246, yeah but there many islands on Earth. Why that one specifically?
MagsElber
3 out of 100 comes to a big number for a large population
Master Rakko
Very interesting! First time I read something about this. .... a very intriguing condition.
Player #13286156
SilkenTract, and why not Haiti since it's the same island?
Stephanie.S.
3 out of 100 seems a lot to me. It would be very difficult to cope with in less tolerant times... which isn't long ago.
SunnyDee
Very interesting. Always learning with this game.
Ducky
Also occurs in Papua New Guinea and Turkey among isolated communities with a lot of inbreeding
Olly
Having now done a fair amount of googling, it rather seems that guevadoces are not fully female at birth, but only have an outward appearance of femaleness, which only makes the condition all the more sad for those affected, for it seems that at puberty the changes to maleness they experience are usually also not complete.
Olly
(cont'd) she would therefore remain female. To be female is to have female genes, which are hers for life, no matter what else happens at puberty. So we seem to have a conundrum here. And I must say there seems to be a tremendous drive these days to blur people's perception of gender!
PerkyLin
NimuaeAvalon, it is not in just Dominican Republic. I have heard of cases in Papua New Guinea and also in Mexico. Probably many other locations too. Some of the children transition to being male easily, having had some male characteristics all along. A minority of them don't want to be male.
Ulrich
SilkenTract, I've read that thers an expression called "balls at 13," in Spanish,but I thought it was about Puerto Rico.
it's not surprising it would occur in a specific population if it's a genetic mutation that isn't caused by external causes, for example, Downs Synrome is not a congenital defect, but occurs most often in older women nearing the end of their child-bearing Yeats, which is something that occurs across cultures and all populations.
Walker
Rare autosomal recessive gene called 17Beta HSD causes same Dufference of Sexual Development. prevalent in Gaza Strip where cousins often marry.
Walker
Colt, Not correct, see my comment
Walker
Player #1380186, Look up Beta HSD3
Walker
This sounds exactly the condition known as Beta HSD3, which is an intersex condition (DSD /difference of sexual development) also common in the Gaza strip.
LimaOscarVictorEcho
Player #1380186, a lot of these questions make me want to research them further.
Wannabe Vulcan
ynkognito1, accident of history, I assume.
Bijou
Gunnar Gunderson, Neanderthal genes are part of the human genome, something like 3%? Their DNA gives us our robust immune systems. Their other physical and mental traits can be seen sometimes, if you look. 😉
Bijou
Margie, Not necessarily. A third cousin or a more distant relative is more likely. If the gene is in a small gene pool, the anomaly will occur in time. Most of the population is related, if only distantly.
Bijou
Player #13286156, There are likely genetic anomalies there too, but perhaps a different one. That particular anomaly may have arisen from a single family on one plantation. Who knows?
Bijou
ynkognito1, Other isolated areas experience the same thing, due to a less diverse gene pool.
Bijou
SilkenTract, Since it is a genetic condition, that gene is more likely to have higher prevalence in communities that are (or were) more isolated from the outside world. The Dominican Republic has a colonial history, during which it was separated physically from "the outside" and the population developed a less diverse gene pool from which offspring would be born. Any genetic anomalies or mutations are more likely to appear in such populations. It is not unusual. Such populations provide a valuable resource for scientific genetic research.
Margie
WhimsicalBruiser9246, could it be from mating with family members?
Stu
the quiz game that keeps on teaching. I've never heard of this condition before. My heart goes out to all who have this
Smeghead
I don't understand the down votes to the perfectly good comments!!
Gunnar Gunderson
Iwonder, Someone should walk Margery Taylor Greene through this and other gender- related abnormalities!!
Melode
WHAT ARE THE ODDS OF THIS GENETIC MUTATION HAPPENING? HOW CAN MALES DEAL WITH THIS?
comotu
WhimsicalBruiser9246, Dominican Republic is not an island. Unless you mention Haiti...and they did not.
Player #21324452
Davy, Livingston, that was Anne Boleyn who had the extra digit, she popularized longer sleeves which covered half the hand in order to hide the deformity
Player #12667706
SilkenTract, they carry the gene
Player Number1Explor
Iwonder, I agree .Was it only entering puberty that a Dr. recognized it for what it was ?
Duckingforcover
This was genuinely fascinating to read. Seems like a traumatic thing to go through.
Player #14000764
Player #3366575, Yes I say that this condition they could not help, as they mature let them choose their gender identity, because they have proof they are born that way. Hormones, the tendency, would not say they are homosexual by choice.
baymax
SilkenTract, it does say common not prevalent!
Player #1281965
MagsElber, still small %