What movie has the lowest US domestic box office opening in US movie history?
Correct answer: Zyzzyx Road (2006)

RushMama2112
Zyzzx Road actually exists. Along I-15 between Las Vegas and L.A., just east of Baker, Ca. It leads to an abandoned spa/resort.

GrumpyChalk8
RushMama2112, There is also another one East of Albuquerque N.M. on I 40.

Rick-N-Bacher
Heigl and Sizemore are decent actors they should've known this was going to be a bomb when they read the script

TF
GrumpyChalk8, that is the one I recall